| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3422795 | Trends in Microbiology | 2006 | 5 Pages |
Abstract
Intracellular bacteria constitute a major class of pathogens for humans and animals. Their pathogenicity is linked to their ability to multiply inside a host cell. A set of virulence genes (virulome) is required for this intracellular lifestyle. Recent studies have shown that blocking the enzymes encoded by these virulence genes impairs intracellular multiplication of the pathogen. These specific factors could constitute a new set of possible targets for antimicrobial drugs. The potential advantages, pitfalls and challenges of a strategy that targets these virulence factors are discussed.
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Authors
Jean-Pierre Liautard, Véronique Jubier-Maurin, Rose-Anne Boigegrain, Stephan Köhler,