Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
37215 | Trends in Biotechnology | 2010 | 9 Pages |
Abstract
Mechanistic models are based on deterministic principles, and recently, interest in them has grown substantially. Herein we present an overview of mechanistic models and their applications in biotechnology, including future perspectives. Model utility is highlighted with respect to selection of variables required for measurement, control and process design. In the near future, mechanistic models with a higher degree of detail will play key roles in the development of efficient next-generation fermentation and biocatalytic processes. Moreover, mechanistic models will be used increasingly in the frame of multi-objective decision-making under uncertainty and to promote increased selectivity of products.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Krist V. Gernaey, Anna Eliasson Lantz, Pär Tufvesson, John M. Woodley, Gürkan Sin,