Article ID Journal Published Year Pages File Type
385972 Expert Systems with Applications 2011 7 Pages PDF
Abstract

Research on peptide classification problems has focused mainly on the study of different encodings and the application of several classification algorithms to achieve improved prediction accuracies. The main drawback of the literature is the lack of an extensive comparison among the available encoding methods on a wide range of classification problems. This paper addresses the fundamental issue of which peptide encoding promises the best results for machine learning classifiers. Two novel encoding methods based on physicochemical properties of the amino acids are proposed and an extensive comparison with several standard encoding methods is performed on three different classification problems (HIV-protease, recognition of T-cell epitopes and prediction of peptides that bind human leukocyte antigens). The experimental results demonstrate the effectiveness of the new encodings and show that the frequently used orthonormal encoding is inferior compared to other methods.

Research highlights► Novel encodings for peptides are proposed. ► High performing pepide classification system. ► Machine learning approach for peptide classification.

Related Topics
Physical Sciences and Engineering Computer Science Artificial Intelligence
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