What has gene expression profiling taught us about glaucoma?

The availability in recent years of new cellular and animal models, as well as advances in genomic and related technologies, have made possible important advances in our understanding of the cellular and molecular events that mediate retinal ganglion cell dysfunction and death in glaucoma. In this review, we briefly summarize the methodology and results of a number of genome-wide expression studies that have been performed to study the retina and optic nerve head in glaucoma.

► Expression profiling has aided in understanding glaucoma pathogenesis. ► Role of neuroinflammation in glaucoma. ► Gene expression changes associated with optic nerve head remodeling. ► Insights into mechanisms of RGC injury and cell death.