Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4011659 | Experimental Eye Research | 2010 | 6 Pages |
Abstract
Traditional ocular pharmacokinetic studies are invasive and cannot be easily applied to humans in vivo. To acquire in vivo ocular pharmacokinetic data noninvasively, 19F MR on a 3T clinical scanner was used to follow the real time dynamics of a corticosteroid in the eye. 1H MR was also performed to locate the site of administration. Triamcinolone acetonide phosphate (TAP) was the model drug, administered by intravitreal and subconjunctival injections. TAP pharmacokinetics were monitored by changes in the 19F spectrum of the intraocular drug in real time. The elimination half-lives of TAP in the eye after intravitreal and subconjunctival injections were 8 and 0.5Â h in vivo and 17 and 6.0Â h postmortem, respectively. The half-lives associated with clearance were 14Â h for intravitreal injection and 0.5Â h for subconjunctival injection.
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Authors
Xin Liu, S. Kevin Li, Eun-Kee Jeong,