Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
404303 | Neural Networks | 2011 | 8 Pages |
Abstract
It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters. Here, we investigate how plasticity is shaped by feedback inhibition in a cortical microcircuit. We use a differential Hebbian learning rule to model spike-timing-dependent plasticity and show analytically that the feedback inhibition shortens the time window for LTD during spike-timing-dependent plasticity but not for LTP. We then use a realistic GENESIS model to test two hypothesis about interneuron hypofunction and conclude that a reduction in GAD67 is the most likely candidate as the cause for hypofrontality as observed in Schizophrenia.
Related Topics
Physical Sciences and Engineering
Computer Science
Artificial Intelligence
Authors
Bernd Porr, Lynsey McCabe, Paolo di Prodi, Christoph Kolodziejski, Florentin Wörgötter,