Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
417497 | Computational Statistics & Data Analysis | 2013 | 9 Pages |
Abstract
This paper develops a unified method to compute the exact statistical power for a general class of response adaptive designs including the randomized play-the-winner design, the drop-the-loser design, and the doubly biased coin design. The adaptation of treatment allocation in response adaptive designs is formulated as a Markov chain. The exact statistical power is computed based on the transition probability of the formulated Markov chain. The proposed approach is demonstrated through the ECMO trial example. The difference between the asymptotic and exact statistical power is also explored for large sample sizes.
Keywords
Related Topics
Physical Sciences and Engineering
Computer Science
Computational Theory and Mathematics
Authors
Yanqing Yi,