Article ID Journal Published Year Pages File Type
421382 Discrete Applied Mathematics 2008 12 Pages PDF
Abstract

We compare complete genomes from common words denoted MUMs for maximum unique matches. They allow to transform each genome into a linear order. We first evaluate the minimum length of a MUM shared by two genomes to be significant. Secondly, we compute maximal common chains of elements, that are in the same order in genomes. From these chains we define conserved genome segments as long DNA fragments having MUMs in the same order and with a bounded gap length between them. The resulting small number of segments allow to detect main evolutionary events as reversal or transposition of these fragments.

Related Topics
Physical Sciences and Engineering Computer Science Computational Theory and Mathematics
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