Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4313827 | Behavioural Brain Research | 2011 | 4 Pages |
Abstract
In rodents, exposure to acute inescapable, but not escapable, stress potentiates morphine conditioned place preference (CPP), an effect that is dependent upon hyperactivation of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN). Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP.
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Authors
Robert R. Rozeske, Benjamin N. Greenwood, Monika Fleshner, Linda R. Watkins, Steven F. Maier,