Article ID Journal Published Year Pages File Type
4360845 Cell Host & Microbe 2016 7 Pages PDF
Abstract

Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.

Related Topics
Life Sciences Immunology and Microbiology Microbiology
Authors
, ,