Manipulation of the Eukaryotic Transcriptional Machinery by Bacterial Pathogens

Pathogenic bacteria inject a diverse set of effectors into eukaryotic host cells and manipulate the cellular environment to enhance bacterial fitness. There is mounting evidence that the transcription machinery in the nucleus of plant cells is a target of various bacterial effectors. These effectors seem to mimic the actions of host nuclear components. To monitor and counteract such virulence-promoting strategies, plants have acquired unique immune-sensing mechanisms.