| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4361512 | Cell Host & Microbe | 2010 | 5 Pages |
Abstract
The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1β and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.
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Authors
Debra J. Taxman, Max T.-H. Huang, Jenny P.-Y. Ting,