| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4361587 | Cell Host & Microbe | 2007 | 4 Pages |
Abstract
SummaryMucosal epithelial cells are a major barrier restricting pathogen entry and, paradoxically, an important entry port for respiratory and enteric viruses. Elegant studies in this issue of Cell Host & Microbe describe how coxsackievirus B3 (related to human poliovirus) infects polarized epithelial cells by engaging two transmembrane proteins of the tight junctions, occludin and CAR. A distinctive endocytic mechanism opens the junctions and gates infectious virus entry.
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Authors
Urs F. Greber, Michele Gastaldelli,