Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4361742 | Cell Host & Microbe | 2008 | 10 Pages |
Abstract
SummaryCatch bonds are bonds between a ligand and its receptor that are enhanced by mechanical force pulling the ligand-receptor complex apart. To date, catch-bond formation has been documented for the most common Escherichia coli adhesin, FimH, and for P-/L-selectins, universally expressed by leukocytes, platelets, and blood vessel walls. One compelling explanation for catch bonds is that force-induced structural alterations in the receptor protein are allosterically linked to a high-affinity conformation of its ligand-binding pocket. Catch-bond properties are likely to be widespread among adhesive proteins, thus calling for a detailed understanding of their underlying mechanisms and physiological significance.
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Authors
Evgeni V. Sokurenko, Viola Vogel, Wendy E. Thomas,