| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 469310 | Computer Methods and Programs in Biomedicine | 2007 | 10 Pages |
Abstract
The continual reassessment method is a recommended dose escalation design for including patients in phase I clinical trials designed to estimate the maximum tolerated dose. However, for a particular trial, the implementation of these methods requires extensive computer programming. Standard 3 + 3 designs do not require this, but have shown to possess poor statistical properties. np1 is a user friendly computer program which has implemented two continual reassessment methods for simulating and conducting a phase I clinical trial. Several options allow the user to investigate operating characteristics under various scenario.
Related Topics
Physical Sciences and Engineering
Computer Science
Computer Science (General)
Authors
Andrew Kramar, Nadine Houédé, Xavier Paoletti,