Article ID Journal Published Year Pages File Type
471187 Computers & Mathematics with Applications 2008 14 Pages PDF
Abstract

This paper presents efficient algorithms for solving the problem of aligning a protein structure template to a query amino-acid sequence, known as protein threading problem. We consider the problem as a special case of graph matching problem. We give formal graph and integer programming models of the problem. After studying the properties of these models, we propose two kinds of Lagrangian relaxation for solving them. We present experimental results on real-life instances showing the efficiency of our approaches.

Related Topics
Physical Sciences and Engineering Computer Science Computer Science (General)
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