Article ID Journal Published Year Pages File Type
471586 Computers & Mathematics with Applications 2015 14 Pages PDF
Abstract

In this work, we first propose continuous models of an aggressive–invasive cancer which is characterized by its heterogeneity, by its high proliferation rates and by the potential invasion of cancer cells into surrounding tissue. An acidification environment mechanism is included in the models to analyze the level of invasion. Second, we introduce and analyze their discrete versions obtained by an appropriate discretization. Afterwards a chemotherapy treatment with a gradual effect is added, which includes important aspects as resistance and drug toxicity. Finally we make comparisons among different chemotherapy schemes to identify a suitable combination in order to eradicate or to reduce the growth of the tumor.

Related Topics
Physical Sciences and Engineering Computer Science Computer Science (General)
Authors
, ,