Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer

Core-shell hierarchical mesostructured silica nanoparticles for gene and chemodrug co-delivery in sequence: We have successfully developed a “chemical homology” strategy for the fabrication of core-shell hierarchical mesostructured MSNs (H-MSNs) with different-sized mesopores and composition-varied frameworks separately in the core and shell. Especially, surface-functionalized H-MSNs have been successfully constructed to sequentially co-deliver and release P-gp modulator siRNA and anticancer drugs (doxorubicin) to reverse the multidrug resistance of cancer cells.380