Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4752540 | Biotechnology Advances | 2016 | 73 Pages |
Abstract
The interplay between the host and host-associated gut microbiota is an area of increasing interest during the recent decade. From young infants to elderly people, from primitive tribes to modern societies, accumulating evidence has suggested the association of critical physiological roles of gut microbiota in the pathogenesis of a variety of human metabolic, immunological and neurological diseases. Importantly, it appears that the relationship between the gut microbiota and disease is bidirectional, instead of causal or consequential. Personalized nutritional and therapeutic strategies targeting the gut microbiota such as prebiotics, probiotics, drugs and fecal microbiota transplantation may create a new era in the human health.
Keywords
T1DIBD5-hydroxytryptamineHFDSCFAsIBSeCBTLRGLP-1T2DPAI-1PYYNLR5-HTNOD1LPLTFHFMTTMAOSFBNAFLDFIAFIGNfasting-induced adipose factornucleotide-binding oligomerization domain 1GPRMYD88CDIFOSIL-1DSSAMPKLPSNODSPFendocannabinoidAutism spectrum disorderγ-aminobutyric acidShort-chain fatty acidsinterleukin-1Segmented filamentous bacteriaBacteriagerm-freeDiseasecardiovascular diseasenon-alcoholic fatty liver diseaseCrohn's diseaseInflammatory bowel diseaseTrimethylamine N-oxidetumor necrosis factor-αToll-like receptordextran sulphate sodiumType 2 diabetesType 1 diabetesNonobese diabeticCVDHigh fat dietBBBHuman healthirritable bowel syndromeClostridium difficile infectionTNF-αFructooligosaccharidesLipoprotein lipaselipopolysaccharideBlood-brain barrierPlasminogen activator inhibitor-1Gut microbiotaknockoutASDspecific pathogen freeProbioticsadenosine monophosphate-activated protein kinasePrebioticspeptide YYglucagon-like peptide 1fecal microbiota transplantationT follicular helperGABAIntestinal gluconeogenesisNOD-like receptorsG protein-coupled receptor
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Daotong Li, Pan Wang, Pengpu Wang, Xiaosong Hu, Fang Chen,