Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4754073 | Journal of Photochemistry and Photobiology A: Chemistry | 2017 | 39 Pages |
Abstract
Binary mixtures of Pluronics are studied as drug nanocarriers in this work. H2 and Zn 5,10,15,20-tetrakis[4-(benzyloxy) phenyl] porphyrin were encapsulated onto binary micelle mixture of Pluronic F127/P123. The fluorescence and singlet oxygen generating behaviour of the porphyrins were investigated following incorporation. The fluorescence quantum yield for H2TBnOPP (ΦF = 0.034) was higher than that of ZnTBnOPP (ΦF = 0.023) and decreased when ZnTBnOPP or H2TBnOPP when in the presence of Pluronic F127/P123 binary mixtures. The kq values were 2.8 Ã 108 and 3.7 Ã 108 Mâ1 sâ1, for H2TBnOPP + Pluronic F127/P123 and ZnTBnOPP + Pluronic F127/P123 in water, respectively. The binding constants (Kb) were 1.58 Ã 105 Mâ1 and 1.02 Ã 105 Mâ1 for ZnTBnOPP + Pluronic F127/P123 and H2TBnOPP + Pluronic F127/P123, respectively.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Muthumuni Managa, Bokolombe Pitchou Ngoy, Tebello Nyokong,