Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4754872 | New Biotechnology | 2017 | 7 Pages |
Abstract
Bispecific IgG-like antibodies can simultaneously interact with two epitopes on the same or on different antigens. Therefore, these molecules facilitate novel modes of action, which cannot be addressed by conventional monospecific IgGs. However, the generation of such antibodies still appears to be demanding due to their specific architecture comprising four different polypeptide chains that need to assemble correctly. This review focusses on different strategies to circumvent this issue or to enforce a correct chain association with a focus on common-chain bispecific antibodies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Simon Krah, Carolin Sellmann, Laura Rhiel, Christian Schröter, Stephan Dickgiesser, Jan Beck, Stefan Zielonka, Lars Toleikis, Björn Hock, Harald Kolmar, Stefan Becker,