| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4755052 | Process Biochemistry | 2017 | 8 Pages |
Abstract
The asymmetric bioreduction of several saturated N-heterocyclic ketones is demonstrated in a stereo-complementary fashion using the ketoreductases READH and ChKRED20 for the production of (S)- and (R)-alcohols, respectively. The reaction accepts substrates with a five-, six- or seven-membered ring, and exhibits excellent stereoselectivity when using 2-propanol as both the ultimate reducing agent and cosolvent, achieve >99% ee in the majority of cases for both enantiomers.
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Bioengineering
Authors
Chao Li, Yan Liu, Xiao-Qiong Pei, Zhong-Liu Wu,