Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4788 | Biochemical Engineering Journal | 2007 | 13 Pages |
Abstract
Fed-batch fermentation for maximization of metabolite production at a final time is normally a singular control problem. The singular optimal feed rate strategy depends on relative position of peaks in the specific rates of cell growth μ, substrate consumption σ and product formation π. Regions in which singular feed rates exist are identified and variation of substrate concentration in the singular region is elucidated. Sufficient conditions for the existence of a singular arc are developed, which can be incorporated into an efficient and stable computational scheme to obtain the optimal feed rate profiles.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Hwa Sung Shin, Henry C. Lim,