Candida rugosa lipase catalysed preparation of l-prolyl, l-phenylalanyl, l-tryptophanyl and l-histidyl esters of carbohydrates

l-Amino acyl (1–4) esters of carbohydrates (5–15) were synthesized through Candida rugosa lipase catalysis in non-polar solvent with yields in the range of 7–79%. In a reaction, involving unprotected and unactivated l-amino acids and carbohydrates, both monoesters (1-O-, 2-O-, 3-O-, 4-O-, 5-O-, 6-O- and 6′-O-) and diesters (1,6-di-O-, 2,5-di-O-, 2,6-di-O-, 3,6-di-O-, 4,6-di-O- and 6,6′-di-O-) were found to be formed in different proportions depending on the l-amino acids and carbohydrates employed. Among 80 individual esters synthesized by this procedure, 67 are being reported for the first time.