Implementing a Domain-specific Language for Model-based Drug Development

In this paper, we present the implementation of a novel domain-specific language (DSL) for pharmacometric modeling called the Modelling Description Language (MDL). MDL is a modular, declarative language with block structures that allows users to abstract data, processes and mathematical models from auxiliary code, and hence, improves model readability, reusability and opportunities for collaborative research. The main aim of this DSL is interoperability between core software tools used in pharmacometrics. We describe the MDL-IDE, an integrated development environment for MDL, which assists users in writing MDL code. The paper focuses on language constructs and design decisions, briefly explains how models are validated and converted to a machine-readable format for processing by existing model simulation and estimation software tools.