A Computational and Mathematical Approach towards the Design and Synthesis of Uniform Au Seed Decorated Fe3O4 Nanoparticle for Potential Bio-application

In recent years, superparamagnetic iron oxide nanoparticles (SPION) with appropriate surface chemistry have been widely used. Au coated form of SPION or bimetallic nanocomposite have also gained considerable interest of scientists because of their unique and tunable properties. In this study we attempt to design a uniform gold nano seed decorated SPION having affinity towards biomolecular attachment. The design has been optimized to estimate the number of gold nano-seeds by various mathematical models to cover up the magnetic core with uniform distribution. Computational modeling has also been used in the design. The process of wet lab synthesis of the designed nanocomposite has also been developed. Finally the characterization proves the successful design and synthesis of the desired nanocomposite. Provision of biomolecular attachment onto the nanocomposite serves as a possible diverse application of this nanocomposite in various biological systems.