Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4933727 | Psychiatry Research | 2017 | 15 Pages |
Abstract
Serotonergic neurotransmission dysfunctions have been well documented in patients with suicidal behaviour. We investigated monoamine oxidase A (MAOA: rs2064070, rs6323, rs909525) and BÂ (MAOB: rs1799836, rs2311013, rs2205655) genetic modulation of personality traits (Temperament and Character Inventory, TCI) as endophenotype for suicidal behaviour. 108 suicide attempters and 286 healthy controls of German origin were screened. Among females, allelic analyses revealed associations between MAOA rs6323 A allele and higher Harm Avoidance in suicide attempters and MAOB rs2205655 A allele and higher Cooperativeness scores in healthy controls. Among males, MAOA rs909525 A allele was associated with higher Reward Dependence in suicide attempters. Multivariate analyses controlling for age and educational level mainly confirmed results. Case-control analyses in this subsample do not differ from our previously reported one. Despite of the small sample size, a possible involvement of these genes in the modulation of personality traits closely related to suicidal behaviour cannot be excluded.
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Martina Balestri, Raffaella Calati, Alessandro Serretti, Annette M. Hartmann, Bettina Konte, Marion Friedl, Ina Giegling, Dan Rujescu,