Helicobacter Pylori infection detection from gastric X-ray images based on feature fusion and decision fusion

In this paper, a fully automatic method for detection of Helicobacter pylori (H. pylori) infection is presented with the aim of constructing a computer-aided diagnosis (CAD) system. In order to realize a CAD system with good performance for detection of H. pylori infection, we focus on the following characteristic of stomach X-ray examination. The accuracy of X-ray examination differs depending on the symptom of H. pylori infection that is focused on and the position from which X-ray images are taken. Therefore, doctors have to comprehensively assess the symptoms and positions. In order to introduce the idea of doctors' assessment into the CAD system, we newly propose a method for detection of H. pylori infection based on the combined use of feature fusion and decision fusion. As a feature fusion scheme, we adopt Multiple Kernel Learning (MKL). Since MKL can combine several features with determination of their weights, it can represent the differences in symptoms. By constructing an MKL classifier for each position, we can obtain several detection results. Furthermore, we introduce confidence-based decision fusion, which can consider the relationship between the classifier's performance and the detection results. Consequently, accurate detection of H. pylori infection becomes possible by the proposed method. Experimental results obtained by applying the proposed method to real X-ray images show that our method has good performance, close to the results of detection by specialists, and indicate that the realization of a CAD system for determining the risk of H. pylori infection is possible.