| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4964998 | Computers in Biology and Medicine | 2017 | 35 Pages |
Abstract
Herein, we review the basic concepts, methods, resources and software tools used for the reconstruction and application of GEMs. We overview the evolution of the modelling efforts devoted to the metabolism of Chinese Hamster Ovary (CHO) cells. We present a case study on CHO cell metabolism under different amino acid depletions. This leads us to the identification of the most influential as well as essential amino acids in selected CHO cell lines.
Keywords
Related Topics
Physical Sciences and Engineering
Computer Science
Computer Science Applications
Authors
Živa Rejc, Lidija Magdevska, Tilen TrÅ¡eliÄ, Timotej Osolin, Rok Vodopivec, Jakob Mraz, Eva Pavliha, Nikolaj Zimic, Tanja CvitanoviÄ, Damjana Rozman, Miha MoÅ¡kon, Miha Mraz,