The R implementation of the CRAN package PATHChange, a tool to study genetic pathway alterations in transcriptomic data

•The package performs multi-statistic analysis to detect differentially expressed pathways in transcriptomic data.•Developed in R available for download from CRAN.•Tutorial with sample problem application.

Tools that extract phenotype alterations from transcriptomic data are important to improve the interpretation of biological studies. PATHChange is a statistical CRAN package designed to work with data downloaded from the Gene Expression Omnibus database (GEO) to determine differential pathway expression in comparative studies including control samples. In this paper we present details of the structure, implementation and an example of use of the package.