Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4976158 | Journal of the Franklin Institute | 2011 | 9 Pages |
Abstract
Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles. In this paper, we examined the kinetics of acoustic release of doxorubicin using stabilized and non-stabilized micelles. Kinetic models were used to regress release and re-encapsulation time constants for three different compounds, namely non-stabilized Pluronic® P105 micelles, P105 micelles stabilized using an interpenetrating network of N,N-diethylacrylamide and micelles formed by PEO-b-poly(NIPAAm-co-HEMA-lactaten). Results showed that the kinetic release constant (kr) depends on the micellar system under investigation. On the other hand, there is no statistically significant difference between re-encapsulation rate constants for stabilized and unstabilized micelles. We hypothesize that kr depends on the degree of cross-linking or stabilization.
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Authors
Ghaleb A. Husseini, Mario A. Diaz de la Rosa, Emad O. AlAqqad, Saif Al Mamary, Yaman Kadimati, Abdullah Al Baik, William G. Pitt,