| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4982213 | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2017 | 22 Pages |
Abstract
In this study, we designed a kind of photoresponsive hydrogel microsphere for three-dimensional (3D) cell culture, which is based on the host-guest interaction of β-cyclodextrin (β-CD) and Azobenzene. The hydrogel microsphere consists of polyethylene glycol (PEG) and β-CD modified poly(methyl vinyl ether-alt-maleic acid) (PMVE-alt-MA) which was allowed to assemble with azobenzene-arginine-glycine-aspartate (Azo-RGD) via host-guest interaction for controlling cell adhesion and detachment. UV irradiation led to the detachment of Azo-RGD from hydrogel microsphere, and the number of cells cultured on the hydrogel microsphere surface was reduced subsequently. This photo-switchable surface can achieve the controllability of cells adhesion and detachment.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Dandan Ma, Naizhen Zhou, Tianzhu Zhang, Ke Hu, Xiao'e Ma, Ning Gu,