A microfluidic device with integrated coaxial nanofibre membranes for optical determination of glucose

Furthermore, this coaxial material was integrated into a microfluidic chip and its sensitivity to glucose was tested (LOD of 35 μM and LOQ of 105 μM), obtaining higher sensing properties than using the membrane alone under ambient conditions. This improvement in the sensing response can be explained by considering that the chip limits the oxygen transfer from the ambient air to the coaxial membrane, creating a more controlled environment in where to carry out the measurements. Therefore, the combination of this core-shell material with microfluidic devices could have great potential in the fabrication of oxygen dependent optical biosensors.