Article ID Journal Published Year Pages File Type
5008920 Sensors and Actuators B: Chemical 2017 7 Pages PDF
Abstract

•Magnetic biochips based on switchable magnetic nano-traps were developed.•They were optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution.•The presence of synthetic peptides trapped on the magnetic wire was revealed via fluorescently labeled immunoglobulins.

Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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