Fabrication of 1,4-bis(aminomethyl)benzene and cobalt hydroxide @ graphene oxide for selective detection of dopamine in the presence of ascorbic acid and serotonin

A simple electrochemical sensor for detecting dopamine was fabricated using 1,4-bis(aminomethyl)benzene (BAMB) and cobalt hydroxide (Co(OH)2) at graphene oxide (GO) surface using a simple solution-based chemical reduction method. The successful formation of GO-BAMB-Co(OH)2 was confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy, while the electrochemical performance of the material was studied using different techniques, including cyclic voltammetry, differential pulse voltammetry, linear sweep voltammetry, and chronoamperometry in 0.1 M PBS at pH 7.4. The GO-BAMB-Co(OH)2-modified electrode showed an excellent electrochemical response with a broad linear range (3-20 and 25-100 μM) and low limit of detection (0.4 μM). Furthermore, efficient selective detection of dopamine in the presence of a 10-fold excess concentration of bio-interfering species, such as ascorbic acid and serotonin, was remarkable. The practical feasibility of the sensor was checked using urine samples, which showed appreciable recovery results. The main advantages of this sensor are its simple electrode fabrication procedure, rapid sensing response, remarkable selectivity, repeatability, and stability.