Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5031565 | Biosensors and Bioelectronics | 2017 | 63 Pages |
Abstract
The importance of developing new diagnostic and detection technologies for the growing number of sensing challenges is rising each year. Here, we present a comprehensive and concise review on electrochemiluminescent (ECL) aptasensors by putting special emphasis on its characteristic features, advances, challenges, and applications of ECL based aptasensors. ECL is an ideal tool for constructing such sensors because of its inherent characteristics and can be easily integrated into aptamer based sensing platforms. This review summarizes the "synergistic benefits" of ECL aptamer-based sensors; classifications of ECL aptamer-based assay designs, and signal amplification strategies. This critical review highlights the effects of integration of nanomaterials, immobilization techniques, and amplification/detection strategies on the analytical performance of ECL based aptasensors. Moreover, several proof-of-concepts with appropriate figures and explanations have been shown to provide a general guide for the design of ECL aptasensors, and to stimulate further application of these ECL aptasensors. Finally, we conclude with the remaining challenges and opportunities to inspire further developments in ECL aptasensors.
Keywords
MCHTGAMoS2PSSCTSMWNTsSNPsTBAtPAHRPGCEDMBAECLNHSPEIMBSMBAssDNAdouble strand DNACy5SWCNTsN-hydroxysuccinimideAptasensorPtNPsPHMSPCEABEIEDCABARCA6-Mercapto-1-hexanolAuNPsBSASingle-stranded DNAComplementary DNAds-DNAhrcANPsPNNsrGOAdenosine TriphosphateATPbovine serum albuminStreptavidinThioglycolic acidChlorogenic acidScreen-printed carbon electrodeglassy carbon electrodeElectrochemiluminescenceEnergy transferresonance energy transferGraphene oxideReduced graphene oxideIntercalationTripropylamineSPRSurface plasmon resonanceAmplificationLoop-mediated isothermal amplificationRolling circle amplificationHyperbranched rolling circle amplificationAdsorptionLOD یا Limit of detectionRETMolybdenum disulfideCyanine dyeStructure-switchingcyclodextrinsferroceneLAMPMalachite greenlimit of detectionMultiwalled carbon nanotubesNanoparticlesPt nanoparticlesSilica nanoparticlesGold nanoparticlesAligned carbon nanotubesSingle-walled Carbon NanotubesNafionquantum dotsHybridizationpolymerase chain reactionPCRgraphene sheetsHorseradish peroxidasePoly(ethylenimine)Polystyrene sulfonateMolecular beaconCaPChloramphenicolQuenchingChitosanGraphene
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Kateryna Muzyka, Muhammad Saqib, Zhongyuan Liu, Wei Zhang, Guobao Xu,