Article ID Journal Published Year Pages File Type
505787 Computers in Biology and Medicine 2009 11 Pages PDF
Abstract

The complex CDK3–cyclin is involved in the control of the progression of G0. While the mechanisms governing early and late G1 progression are well understood, very little is known about the G0–G1 transition. Human CDK3 is closely related to cyclin-dependent kinase 2 (CDK2). Since there is no crystallographic structure of human CDK3, this work describes for the first time a molecular model of human CDK3 complexed with several inhibitors. Comparison of the binary complexes with different inhibitors strongly indicates that those inhibitors should inhibit CDK3 as well as CDK2.

Related Topics
Physical Sciences and Engineering Computer Science Computer Science Applications
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