Development of a computer-aided diagnosis system for continuous peritoneal dialysis: An availability of the simultaneous numerical optimization technique for kinetic parameters in the peritoneal dialysis model

We developed a novel diagnostic system for continuous peritoneal dialysis, which evaluates the peritoneal permeability and hydraulic conductance (peritoneal function) by applying the kinetic model and a clinical test with minimum nursing time. Kinetic parameters for the peritoneal function were determined by the simultaneous numerical optimization techniques (SNOT). Furthermore dialysis outcome and ultrafiltration volume were estimated and predicted by using the kinetic model with a set of optimal kinetic parameters, which were in agreement with measured data (r2>0.82)(r2>0.82). The clinical implementation of the SNOT is very useful to explore the better prescriptions for each patient's clinical condition.