Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
506113 | Computers in Biology and Medicine | 2008 | 9 Pages |
Abstract
Missing values in microarray data can significantly affect subsequent analysis, thus it is important to estimate these missing values accurately. In this paper, a sequential local least squares imputation (SLLSimpute) method is proposed to solve this problem. It estimates missing values sequentially from the gene containing the fewest missing values and partially utilizes these estimated values. In addition, an automatic parameter selection algorithm, which can generate an appropriate number of neighboring genes for each target gene, is presented for parameter estimation. Experimental results confirmed that SLLSimpute method exhibited better estimation ability compared with other currently used imputation methods.
Related Topics
Physical Sciences and Engineering
Computer Science
Computer Science Applications
Authors
Xiaobai Zhang, Xiaofeng Song, Huinan Wang, Huanping Zhang,