Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
510071 | Computers & Structures | 2011 | 13 Pages |
Abstract
Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantitate the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.
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Computer Science Applications
Authors
Aiping Liu, Andrew Nickerson, Aaron Troyer, Xin Yin, Robert Cary, Kent Thornburg, Ruikang Wang, Sandra Rugonyi,