Article ID Journal Published Year Pages File Type
5121965 Journal of Clinical Epidemiology 2016 9 Pages PDF
Abstract

ObjectiveTo describe methods to determine sample sizes in surveys using open-ended questions and to assess how resampling methods can be used to determine data saturation in these surveys.Study Design and SettingWe searched the literature for surveys with open-ended questions and assessed the methods used to determine sample size in 100 studies selected at random. Then, we used Monte Carlo simulations on data from a previous study on the burden of treatment to assess the probability of identifying new themes as a function of the number of patients recruited.ResultsIn the literature, 85% of researchers used a convenience sample, with a median size of 167 participants (interquartile range [IQR] = 69-406). In our simulation study, the probability of identifying at least one new theme for the next included subject was 32%, 24%, and 12% after the inclusion of 30, 50, and 100 subjects, respectively. The inclusion of 150 participants at random resulted in the identification of 92% themes (IQR = 91-93%) identified in the original study.ConclusionIn our study, data saturation was most certainly reached for samples >150 participants. Our method may be used to determine when to continue the study to find new themes or stop because of futility.

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