Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5122005 | Journal of Clinical Epidemiology | 2016 | 6 Pages |
Abstract
Many analyses of observational data are attempts to emulate a target trial. The emulation of the target trial may fail when researchers deviate from simple principles that guide the design and analysis of randomized experiments. We review a framework to describe and prevent biases, including immortal time bias, that result from a failure to align start of follow-up, specification of eligibility, and treatment assignment. We review some analytic approaches to avoid these problems in comparative effectiveness or safety research.
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Authors
Miguel A. Hernán, Brian C. Sauer, Sonia Hernández-DÃaz, Robert Platt, Ian Shrier,