Article ID Journal Published Year Pages File Type
5130782 Analytica Chimica Acta 2017 10 Pages PDF
Abstract

•Simple and efficient approach for sample pretreatment of complex matrices.•Membrane impregnated with switchable hydrophilicity solvent for microextraction.•Switchable hydrophilicity solvent membrane-based microextraction coupled witch HPLC-FLD.•HPLC-FLD determination of fluoroquinolones in shrimps.

A switchable hydrophilicity solvent membrane-based microextraction (SHS-MME) strategy for simple and highly-available sample pretreatment of complex matrices has been proposed. The SHS-MME procedure based on extraction of target analytes from an aqueous sample into a porous hydrophobic membrane impregnated with a switchable hydrophilicity solvent (SHS) followed by SHS ionization and back-extraction of the analytes in alkaline acceptor solution. The medium-chain fatty acids were investigated as SHS for the SHS-MME of fluoroquinolones (fleroxacin, lomefloxacin, norfloxacin and ofloxacin). The SHS-MME was successfully coupled with a HPLC-FLD for the determination of fluoroquinolones in shrimp samples with no further sample pretreatment. The calibration graphs were linear over the concentration ranges of 3-1500 μg L−1 for ofloxacin, 10-1000 μg L−1 for norfloxacin, 15-1500 μg L−1 for lomefloxacin and fleroxacin. The limits of detection, calculated from a blank test based on 3σ, were 1 μg L−1 for ofloxacin, 3 μg L−1 for norfloxacin and 5 μg L−1 for lomefloxacin and fleroxacin. The SHS ionization can be considered as new potential fields in analytical application of membrane-based liquid phase microextraction.

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Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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