Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5131217 | Analytica Chimica Acta | 2016 | 9 Pages |
Abstract
Comprehensive carbohydrate analysis of glycoproteins from human biological samples and biotherapeutics are important from diagnostic and therapeutic points of view. This review summarizes the current state-of-the-art liquid phase separation techniques used in N-glycosylation analysis. The different liquid chromatographic techniques and capillary electrophoresis methods are critically discussed in detail. Miniaturization of these methods is also important to increase throughput and decrease analysis time. The sample preparation and labeling methods for asparagine linked oligosaccharides are also addressed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Laszlo Hajba, Eszter Csanky, Andras Guttman,