Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5131305 | Analytica Chimica Acta | 2016 | 8 Pages |
â¢The probe is structurally simple and easy to synthesize.â¢The probe shows pH dependent dual-selectivity for Zn2+ and Al3+ in Tris-HCl buffer.â¢The probe has good cell-permeability and selectively sense intracellular Zn2+ and Al3+ by bioimaging at different pH.â¢The probe can be used for determination of the analytes in real drug samples.
A Schiff base-type fluorescent probe (1) consist of 2-hydroxynaphthaldehyde and glutamide moieties has been designed and synthesized for detection Zn2+ and Al3+. The probe shows pH dependent dual-selectivity for Zn2+ and Al3+ in Tris-HCl buffer, viz. that can selectively recognized Zn2+ at pH 7.4 and Al3+ at pH 6.0, respectively. From Job's plots and MS data, the stoichiometric ratios of the probe with Zn2+ and Al3+ appeared to be 1:1 and 2:1, respectively. The probe can detect as low as 5.5Â ÃÂ 10â8Â Mâ1 Zn2+ and 1.27Â ÃÂ 10â7Â Mâ1 Al3+, whereas respective association constants are 4.27Â ÃÂ 104Â Mâ1 and 3.50Â ÃÂ 109Â Mâ1. Furthermore, it is also confirmed that the probe has good cell-permeability and could thus be used to selectively sense intracellular Zn2+ and Al3+ by bioimaging in different pH environment. Finally the probe has been used successfully for determination of the analytes in real drug samples.
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