Application of MoS2 modified screen-printed electrodes for highly sensitive detection of bovine serum albumin

•MoS2 nanoflakes have been used for an electrochemical immunosensor.•The sensor's response was proportional to the antigen concentration.•Highly sensitive and specific detection of iron-binding protein 'BSA' is achieved.•A wide linear range of detection of BSA is demonstrated.

The present work reports the application of a new molybdenum disulphide (MoS2)-based electrochemical platform for highly sensitive quantitation of an iron-binding protein, bovine serum albumin (BSA). The gold screen-printed electrodes were modified with MoS2 nanoflakes, followed by bioconjugation with anti-BSA antibodies. Using the above bioelectrode, cyclic voltammetric analysis was carried out in the presence of a Fe3+/Fe2+ redox probe which exhibited a linear response of peak current with varying concentrations of BSA up to 10 ng/mL (with a detection limit of 0.006 ng/mL). This study is novel in that it shows a considerable enhancement of signal during electrochemical sensing of a protein.

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