Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies

A series of 1, 2,3-triazoles derivatives were synthesized at the C-7′ position of the gomisin B core through click protocol. Among them, cell cycle analysis indicated that compound 5b caused a cell cycle arrest of HeLa cells at G2/M phase and also promoted tubulin polymerization, similar to Paclitaxel. Overall, we identified a novel small molecule that demonstrated anticancer activity by promoting in vivo tubulin assembly.212