Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
517403 | Journal of the American Medical Informatics Association | 2009 | 5 Pages |
Abstract
Time-dependent drug-drug interactions (TDDIs) are drug combinations that result in a decreased drug effect due to coadministration of a second drug. Such interactions can be prevented by separately administering the drugs. This study attempted to reduce drug administration errors due to overridden TDDIs in a care provider order entry (CPOE) system. In four periods divided over two studies, logged TDDIs were investigated by reviewing the time intervals prescribed in the CPOE and recorded on the patient chart. The first study showed significant drug administration error reduction from 56.4 to 36.2% (p < 0.05), whereas the second study was not successful (46.7 and 45.2%; p > 0.05). Despite interventions, drug administration errors still occurred in more than one third of cases and prescribing errors in 79-87%. Probably the low alert specificity, the unclear alert information content, and the inability of the software to support safe and efficient TDDI alert handling all diminished correct prescribing, and consequently, insufficiently reduced drug administration errors.
Related Topics
Physical Sciences and Engineering
Computer Science
Computer Science Applications
Authors
Heleen RPh, PhD, Laureen RPh, Annemieke RPh, Jos PhD, Marc MD, MA, PhD, Arnold RPh, PhD, Teun MD, PhD,