Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5208152 | Progress in Polymer Science | 2014 | 36 Pages |
Abstract
Cells respond to their environment in complex and sometimes poorly understood ways. Protein, peptide and synthetic peptidomimetic ligands may all be used to stimulate cells via receptor signaling, using interactions that are often highly specific. Polymer substrates that present these ligands provide a promising way to control cell development, both for applications in biotechnology and for fundamental studies of cell biology. Here we review a large range of techniques that have been employed to create and characterize ligand-functionalized substrates, with a particular focus on techniques that allow specific and consistent stimulation.
Keywords
DPNATRPCTACDINTAbFGFSAMBioconjugationLbLCNTFFGFBCANGFGAGAFMμCPIPNEBLNCP2D/3DNMPSMCCGNPCuAACEDC/NHSLIFTGF-βTBTAECMPDMSEGFPI3KMMPOrientationBSAERK/MAPKl-3,4-dihydroxyphenylalaninel-DOPATof-SIMSbovine serum albuminamino acidnitriloacetic acidUltravioletAtom transfer radical polymerizationFörster resonance energy transferFRETReversible addition-fragmentation chain transferImmobilizationbicinchoninic acidTransforming Growth Factor BetaEnzyme-linked immunosorbent assayELISANMRSurface plasmon resonanceSPRSelf-assembled monolayerAttachmentRAFTCAMConformationInterpenetrating polymer networkSAPTime-of-Flight Secondary Ion Mass SpectrometryNuclear magnetic resonance spectroscopyX-ray photoelectron spectroscopyXPSChain transfer agentepidermal growth factorleukaemia inhibitory factorGrowth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nerve growth factorfibroblast growth factorbasic fibroblast growth factorciliary neurotrophic factorphosphoinositide 3-kinaseElectron beam lithographyExtracellular matrixmatrix metalloproteinaseInfraredCell adhesion moleculequartz crystal microbalanceQCMGold nanoparticleDip-pen nanolithographyPoly (ethylene glycol)Nitroxide-mediated polymerizationPEGPolydimethylsiloxaneSelf-assembling peptideMicrocontact printinghigh performance liquid chromatographyHPLCGlycosaminoglycan
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Andrew E. Rodda, Laurence Meagher, David R. Nisbet, John S. Forsythe,