| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212297 | Tetrahedron | 2017 | 7 Pages |
Abstract
We have accomplished the first total synthesis of STAT3 inhibitory (â)-phaeosphaeride A and its stereoisomer (â)-phaeosphaeride B. This work confirms the configurational assignment of these natural products. Notably, TFA-mediated dehydrative stereoinversion of phaeosphaeride A afforded phaeosphaeride B, based on our hypothesis of the biosynthesis mechanism of phaeosphaeride B from phaeosphaeride A.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenichi Kobayashi, Risako Kunimura, Kosaku III, Osamu Tamura, Hiroshi Kogen,